{"id":1622,"date":"2019-08-21T10:20:03","date_gmt":"2019-08-21T10:20:03","guid":{"rendered":"https:\/\/mft.nhs.uk\/mri\/?p=1622"},"modified":"2025-10-23T10:59:34","modified_gmt":"2025-10-23T10:59:34","slug":"first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri","status":"publish","type":"post","link":"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/","title":{"rendered":"First patient treated in global gene therapy trial at Manchester CRF at MRI"},"content":{"rendered":"<h3>The\u00a0<a href=\"https:\/\/research.cmft.nhs.uk\/facilities-services\/clinical-research-facility\">NIHR Manchester Clinical Research Facility<\/a>\u00a0(CRF) at Manchester Royal Infirmary has successfully dosed the first patient in the UK and the first patient to Cohort 2 globally to its phase 1 gene therapy trial to help improve the lives of patients with severe haemophilia A.<\/h3>\n<p>The GET8 research trial is being led locally by Chief Investigator Charles Hay and the Non-Malignant Haematology Research Team at NIHR Manchester Clinical Research Facility (CRF) at Manchester Royal Infirmary. The team have recruited and dosed the first patient to GET8 which is being trialled in human volunteers for the first time across 25 research sites globally.<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-14415\" src=\"https:\/\/research.cmft.nhs.uk\/wp-content\/uploads\/2019\/08\/Non_malignant-research-team-740x268.png\" alt=\"non_malignant-research-team\" width=\"740\" height=\"268\" \/><\/p>\n<p>Haemophilia A is a hereditary bleeding disorder whereby a protein that helps the body to make blood clots is either partly or completely missing. Although it is the most common type of haemophilia it is a rare condition mainly affecting around one in 10,000 males. People with severe haemophilia may bleed one to two times per week into their muscles or joints causing pain, swelling and limited movement and have a tendency to bruise easily and bleed excessively from cuts.<\/p>\n<p>Current treatment for people living with this condition replaces the missing clotting factor VIII in the blood and requires frequent injections on a daily basis for life. GET8 aims to reduce the amount of daily injections by determining the safety and tolerability of a factor VIII gene transfer treatment (a single infusion of adeno-associated virus (AAV) containing DNA with relevant parts of the factor VIII gene).<\/p>\n<p>This trial is supported by the\u00a0<a href=\"https:\/\/local.nihr.ac.uk\/lcrn\/greater-manchester\/\">NIHR Greater Manchester Clinical Research Network<\/a>\u00a0and funded by Bayer PLC.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The\u00a0NIHR Manchester Clinical Research Facility\u00a0(CRF) at Manchester Royal Infirmary has successfully dosed the first patient in the UK and the first patient to Cohort 2 globally to its phase 1 gene therapy trial to help improve the lives of patients with severe haemophilia A. The GET8 research trial is being led locally by Chief Investigator [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":1620,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5],"tags":[],"class_list":["post-1622","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>First patient treated in global gene therapy trial at Manchester CRF at MRI - Manchester Royal Infirmary<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"First patient treated in global gene therapy trial at Manchester CRF at MRI - Manchester Royal Infirmary\" \/>\n<meta property=\"og:description\" content=\"The\u00a0NIHR Manchester Clinical Research Facility\u00a0(CRF) at Manchester Royal Infirmary has successfully dosed the first patient in the UK and the first patient to Cohort 2 globally to its phase 1 gene therapy trial to help improve the lives of patients with severe haemophilia A. The GET8 research trial is being led locally by Chief Investigator [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/\" \/>\n<meta property=\"og:site_name\" content=\"Manchester Royal Infirmary\" \/>\n<meta property=\"article:published_time\" content=\"2019-08-21T10:20:03+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-23T10:59:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/7\/2019\/08\/IMG_3691_d-e1566382783982.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"4272\" \/>\n\t<meta property=\"og:image:height\" content=\"1783\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Kate Pugh\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Kate Pugh\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/\"},\"author\":{\"name\":\"Kate Pugh\",\"@id\":\"https:\/\/mft.nhs.uk\/mri\/#\/schema\/person\/cb39666a02ebff1b7ed1281a3e10e447\"},\"headline\":\"First patient treated in global gene therapy trial at Manchester CRF at MRI\",\"datePublished\":\"2019-08-21T10:20:03+00:00\",\"dateModified\":\"2025-10-23T10:59:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/\"},\"wordCount\":275,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/7\/2019\/08\/IMG_3691_d-e1566382783982.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/\",\"url\":\"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/\",\"name\":\"First patient treated in global gene therapy trial at Manchester CRF at MRI - Manchester Royal Infirmary\",\"isPartOf\":{\"@id\":\"https:\/\/mft.nhs.uk\/mri\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/7\/2019\/08\/IMG_3691_d-e1566382783982.jpg\",\"datePublished\":\"2019-08-21T10:20:03+00:00\",\"dateModified\":\"2025-10-23T10:59:34+00:00\",\"author\":{\"@id\":\"https:\/\/mft.nhs.uk\/mri\/#\/schema\/person\/cb39666a02ebff1b7ed1281a3e10e447\"},\"breadcrumb\":{\"@id\":\"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#primaryimage\",\"url\":\"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/7\/2019\/08\/IMG_3691_d-e1566382783982.jpg\",\"contentUrl\":\"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/7\/2019\/08\/IMG_3691_d-e1566382783982.jpg\",\"width\":4272,\"height\":1783},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/mft.nhs.uk\/mri\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"First patient treated in global gene therapy trial at Manchester CRF at MRI\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/mft.nhs.uk\/mri\/#website\",\"url\":\"https:\/\/mft.nhs.uk\/mri\/\",\"name\":\"Manchester Royal Infirmary\",\"description\":\"Manchester University NHS Foundation Trust -  Manchester Royal Infirmary\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/mft.nhs.uk\/mri\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/mft.nhs.uk\/mri\/#\/schema\/person\/cb39666a02ebff1b7ed1281a3e10e447\",\"name\":\"Kate Pugh\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/mft.nhs.uk\/mri\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/27f703e7c8e028cb48b0714df2098387ee7d35ae39f11a00a4817a1b3bfda8bd?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/27f703e7c8e028cb48b0714df2098387ee7d35ae39f11a00a4817a1b3bfda8bd?s=96&d=mm&r=g\",\"caption\":\"Kate Pugh\"},\"url\":\"https:\/\/mft.nhs.uk\/mri\/author\/katepugh\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"First patient treated in global gene therapy trial at Manchester CRF at MRI - Manchester Royal Infirmary","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/","og_locale":"en_US","og_type":"article","og_title":"First patient treated in global gene therapy trial at Manchester CRF at MRI - Manchester Royal Infirmary","og_description":"The\u00a0NIHR Manchester Clinical Research Facility\u00a0(CRF) at Manchester Royal Infirmary has successfully dosed the first patient in the UK and the first patient to Cohort 2 globally to its phase 1 gene therapy trial to help improve the lives of patients with severe haemophilia A. The GET8 research trial is being led locally by Chief Investigator [&hellip;]","og_url":"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/","og_site_name":"Manchester Royal Infirmary","article_published_time":"2019-08-21T10:20:03+00:00","article_modified_time":"2025-10-23T10:59:34+00:00","og_image":[{"width":4272,"height":1783,"url":"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/7\/2019\/08\/IMG_3691_d-e1566382783982.jpg","type":"image\/jpeg"}],"author":"Kate Pugh","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Kate Pugh","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#article","isPartOf":{"@id":"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/"},"author":{"name":"Kate Pugh","@id":"https:\/\/mft.nhs.uk\/mri\/#\/schema\/person\/cb39666a02ebff1b7ed1281a3e10e447"},"headline":"First patient treated in global gene therapy trial at Manchester CRF at MRI","datePublished":"2019-08-21T10:20:03+00:00","dateModified":"2025-10-23T10:59:34+00:00","mainEntityOfPage":{"@id":"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/"},"wordCount":275,"commentCount":0,"image":{"@id":"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#primaryimage"},"thumbnailUrl":"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/7\/2019\/08\/IMG_3691_d-e1566382783982.jpg","articleSection":["News"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/","url":"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/","name":"First patient treated in global gene therapy trial at Manchester CRF at MRI - Manchester Royal Infirmary","isPartOf":{"@id":"https:\/\/mft.nhs.uk\/mri\/#website"},"primaryImageOfPage":{"@id":"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#primaryimage"},"image":{"@id":"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#primaryimage"},"thumbnailUrl":"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/7\/2019\/08\/IMG_3691_d-e1566382783982.jpg","datePublished":"2019-08-21T10:20:03+00:00","dateModified":"2025-10-23T10:59:34+00:00","author":{"@id":"https:\/\/mft.nhs.uk\/mri\/#\/schema\/person\/cb39666a02ebff1b7ed1281a3e10e447"},"breadcrumb":{"@id":"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#primaryimage","url":"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/7\/2019\/08\/IMG_3691_d-e1566382783982.jpg","contentUrl":"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/7\/2019\/08\/IMG_3691_d-e1566382783982.jpg","width":4272,"height":1783},{"@type":"BreadcrumbList","@id":"https:\/\/mft.nhs.uk\/mri\/first-patient-treated-in-global-gene-therapy-trial-at-manchester-crf-at-mri\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mft.nhs.uk\/mri\/"},{"@type":"ListItem","position":2,"name":"First patient treated in global gene therapy trial at Manchester CRF at MRI"}]},{"@type":"WebSite","@id":"https:\/\/mft.nhs.uk\/mri\/#website","url":"https:\/\/mft.nhs.uk\/mri\/","name":"Manchester Royal Infirmary","description":"Manchester University NHS Foundation Trust -  Manchester Royal Infirmary","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mft.nhs.uk\/mri\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/mft.nhs.uk\/mri\/#\/schema\/person\/cb39666a02ebff1b7ed1281a3e10e447","name":"Kate Pugh","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/mft.nhs.uk\/mri\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/27f703e7c8e028cb48b0714df2098387ee7d35ae39f11a00a4817a1b3bfda8bd?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/27f703e7c8e028cb48b0714df2098387ee7d35ae39f11a00a4817a1b3bfda8bd?s=96&d=mm&r=g","caption":"Kate Pugh"},"url":"https:\/\/mft.nhs.uk\/mri\/author\/katepugh\/"}]}},"_links":{"self":[{"href":"https:\/\/mft.nhs.uk\/mri\/wp-json\/wp\/v2\/posts\/1622","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mft.nhs.uk\/mri\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mft.nhs.uk\/mri\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mft.nhs.uk\/mri\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/mft.nhs.uk\/mri\/wp-json\/wp\/v2\/comments?post=1622"}],"version-history":[{"count":2,"href":"https:\/\/mft.nhs.uk\/mri\/wp-json\/wp\/v2\/posts\/1622\/revisions"}],"predecessor-version":[{"id":1624,"href":"https:\/\/mft.nhs.uk\/mri\/wp-json\/wp\/v2\/posts\/1622\/revisions\/1624"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mft.nhs.uk\/mri\/wp-json\/wp\/v2\/media\/1620"}],"wp:attachment":[{"href":"https:\/\/mft.nhs.uk\/mri\/wp-json\/wp\/v2\/media?parent=1622"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mft.nhs.uk\/mri\/wp-json\/wp\/v2\/categories?post=1622"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mft.nhs.uk\/mri\/wp-json\/wp\/v2\/tags?post=1622"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}