{"id":600,"date":"2018-09-17T10:18:11","date_gmt":"2018-09-17T10:18:11","guid":{"rendered":"https:\/\/mft.nhs.uk\/rmch\/?p=600"},"modified":"2018-10-26T10:23:07","modified_gmt":"2018-10-26T10:23:07","slug":"innovative-paediatric-car-t-therapy-study-meets-recruitment-target","status":"publish","type":"post","link":"https:\/\/mft.nhs.uk\/rmch\/innovative-paediatric-car-t-therapy-study-meets-recruitment-target\/","title":{"rendered":"Innovative paediatric CAR-T therapy study meets recruitment target"},"content":{"rendered":"<h2>Congratulations to the paediatric oncology research team and colleagues in London who have met their recruitment target for an innovative CAR-T therapy study.<\/h2>\n<p>The CARPALL study opened at the Royal Manchester Children\u2019s Hospital (RMCH) in 2015 to evaluate the use of CAR-T therapy in Acute Lymphoblastic Leukemia (ALL) and Burkitt\u2019s lymphoma.<\/p>\n<p>CAR-T therapy involves using a patient\u2019s own cells, which have been altered to recognise and attack the ALL and lymphoma cells to see if it can prevent leukaemia\/lymphoma from coming back.<\/p>\n<p>The study involves taking a patient\u2019s white blood cells and altering them to recognise a protein (CD19) on the surface of ALL and lymphoma cells. The aim is that the modified cells identify the CD19 protein on the cancer cells and attack them.<\/p>\n<p>The study, which has been running for three years, was the first CAR-T study in Europe to show partial and in some cases full remission of cancer in children and young adults with ALL and lymphoma. The study has now been extended to recruit another 18 patients and has also recently opened at Manchester Royal Infirmary.<\/p>\n<p><strong>Professor Rob Wynn, Consultant Paediatric Haematologist and Principal Investigator for the study said:<\/strong><\/p>\n<blockquote><p><em>\u201cThis is an important but intensive study, and I\u2019d like to thank the paediatric oncology research team and wider RMCH in enabling us to provide such an innovative study for our patients.<\/em><\/p>\n<p><em>\u201cBy learning more about new therapies such as CAR-T, we hope to be able to offer more treatment options for young people with blood cancer.\u201d<\/em><\/p><\/blockquote>\n<p>The CARPALL study is sponsored by <a href=\"https:\/\/www.cancerresearchuk.org\/\">Cancer Research UK<\/a> and the <a href=\"http:\/\/www.ctc.ucl.ac.uk\/\">UCL Cancer Trials Centre.<\/a><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/research.cmft.nhs.uk\/assets\/resizer\/resize.php?width=960&amp;cropratio=48:13&amp;image=https:\/\/research.cmft.nhs.uk\/wp-content\/uploads\/2018\/06\/IMG_6722-copyright-Greg-Harding-Photography-2010-e1528704705828.jpg\" alt=\"Innovative paediatric CAR-T therapy study meets recruitment target\" \/><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Congratulations to the paediatric oncology research team and colleagues in London who have met their recruitment target for an innovative CAR-T therapy study. The CARPALL study opened at the Royal Manchester Children\u2019s Hospital (RMCH) in 2015 to evaluate the use of CAR-T therapy in Acute Lymphoblastic Leukemia (ALL) and Burkitt\u2019s lymphoma. CAR-T therapy involves using [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":601,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8,17],"tags":[],"class_list":["post-600","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Innovative paediatric CAR-T therapy study meets recruitment target - Royal Manchester Children&#039;s Hospital<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mft.nhs.uk\/rmch\/innovative-paediatric-car-t-therapy-study-meets-recruitment-target\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Innovative paediatric CAR-T therapy study meets recruitment target - Royal Manchester Children&#039;s Hospital\" \/>\n<meta property=\"og:description\" content=\"Congratulations to the paediatric oncology research team and colleagues in London who have met their recruitment target for an innovative CAR-T therapy study. 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