{"id":5194,"date":"2021-09-07T12:40:03","date_gmt":"2021-09-07T11:40:03","guid":{"rendered":"https:\/\/mft.nhs.uk\/saint-marys\/?p=5194"},"modified":"2021-09-07T11:40:54","modified_gmt":"2021-09-07T11:40:54","slug":"couples-wanted-to-be-part-of-pioneering-male-contraceptive-research-study-nes-t","status":"publish","type":"post","link":"https:\/\/mft.nhs.uk\/saint-marys\/couples-wanted-to-be-part-of-pioneering-male-contraceptive-research-study-nes-t\/","title":{"rendered":"Couples wanted to be part of pioneering male contraceptive research study \u2013 \u2018NES\/T\u2019"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column]<div class=\"c-highlight \">\n    <\/p>\n<h3>Looking to explore an alternative method of birth control? Consider being part of ground-breaking research taking place at <a href=\"https:\/\/mft.nhs.uk\/saint-marys\/\">Saint Mary\u2019s Hospital<\/a>.<\/h3>\n<p>\n<\/div>\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]The <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03452111\">NES\/T study<\/a> is investigating whether daily use of a hormone-based gel is an effective method of contraception for men \u2013 in what could be an historic medical breakthrough and allow men and women to take equal responsibility for birth control in future.<\/p>\n<p>Saint Mary\u2019s Hospital, in Manchester, is one of only two UK sites where the global study is taking place. Participants in the NES\/T trial must be:<\/p>\n<ul>\n<li>in a monogamous relationship (exclusive, with one partner) for more than 12 months<\/li>\n<li>in heterosexual relationship (with someone of the opposite sex)<\/li>\n<li>between 18 and 50-years-old (men)<\/li>\n<li>between 18 and 34-years-old inclusive (women).<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<p class=\"c-content__lead\">\n    For more information about taking part in the NES\/T study, contact the trial team via: contraceptive.trial@mft.uk or 0161 276 3296.\n<\/p>\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h3><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-5197\" src=\"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/4\/2021\/09\/cheryl_fitzgerald.jpg\" alt=\"\" width=\"96\" height=\"96\" srcset=\"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/4\/2021\/09\/cheryl_fitzgerald.jpg 96w, https:\/\/mft.nhs.uk\/app\/uploads\/sites\/4\/2021\/09\/cheryl_fitzgerald-60x60.jpg 60w\" sizes=\"auto, (max-width: 96px) 100vw, 96px\" \/>More about NES\/T<\/h3>\n<p>Dr Cheryl Fitzgerald, Consultant Gynaecologist at Saint Mary\u2019s Hospital and study lead at our Trust, said: \u201cThe NES\/T gel is a hormone-based treatment designed to reduce sperm production, without affecting libido, and works in a very similar way to the female pill.<\/p>\n<p>\u201cIt contains a mixture of progestagen and testosterone \u2013 the progestagen \u2018switches off\u2019 sperm production and the testosterone compensates for the drop in testosterone this causes \u2013 which could otherwise result in unpleasant side-effects.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<!-- Testimonial Box -->\n<section>\n\t<div class=\"c-testimonial-box\">\n\t    <div class=\"o-grid\">   \n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"51\" height=\"48\" viewBox=\"0 0 51 48\"><path id=\"quote\" d=\"M0,48V26.823q0-9.569,3.3-16.157T16.355,0l5.032,9.1q-6.133,2.98-8.178,6.51T11.166,25.1H22.488V48Zm28.354,0V26.823q0-9.569,3.46-16.157T45.024,0l5.032,9.1q-6.133,2.98-8.178,6.51T39.834,25.1H51V48Z\" \/><\/svg>\n\t\t\t\n            <span class=\"c-testimonial-box__text-sub\"> <\/span>\n            <p class=\"c-testimonial-box__text\">Anything that gives people more choice has to be a good thing. The only contraceptive options available for men currently are condoms or vasectomies, and a lot of women struggle with their contraception.\u201d<\/p>\n\t            \n\t    <\/div>\n\t \n\t<\/div>\n<\/section>\n<!-- Testimonial Box  -->\n\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]The study will involve approximately 420 couples worldwide, with many having already taken part in Manchester since the study opened at Saint Mary\u2019s Hospital in April 2019. (Participants are compensated for their time, \u00a375 per visit).<\/p>\n<h3><strong>How the study works<\/strong><\/h3>\n<p>Men participating in the trial are required to rub the gel into their shoulders or chest area once a day. The gel is clear and is quickly absorbed into the skin.<\/p>\n<p>For up to 20 weeks, couples are required to continue using their normal contraceptive method, in conjunction with the hormone gel. Then, when the male partner\u2019s sperm count has fallen below the required level, couples will be asked to rely on the gel as their sole form of contraceptive for the following 12 months.<\/p>\n<p>There is then a \u2018recovery phase\u2019, which can last up to six months, during which the study team carries out follow-up appointments to ensure the male participant\u2019s sperm levels have returned to normal.<\/p>\n<h3><strong>Potential risks<\/strong><\/h3>\n<p>Dr Fitzgerald stressed that while no contraceptive method can be considered 100 per cent effective, the chances of unplanned pregnancy for couples taking part in the trial are very low.<\/p>\n<p>\u201cThe gel has shown to be really effective and safe in early trials and, so far, we are seeing very few side effects.\u201d<\/p>\n<h3><strong>Participant stories<\/strong><\/h3>\n<p>Two couples who have been part of the research at Saint Mary\u2019s Hospital \u2013 Lewis &amp; Jessica and Dan &amp; Emily \u2013 shared their experiences of taking part in the study as part of a BBC Morning Live feature.<\/p>\n<p>Filmed in early 2020, prior to lockdown and social distancing, and first broadcast in March 2021, you can <a href=\"https:\/\/www.bbc.co.uk\/iplayer\/episode\/m000t1bp\/morning-live-series-2-08032021\">watch on BBC iPlayer here, from 30 minutes<\/a>.<\/p>\n<p>Lewis and Jessica, who are 25 and 22 respectively, have been relying on the gel as their sole form of contraception since October 2020.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<!-- Testimonial Box -->\n<section>\n\t<div class=\"c-testimonial-box\">\n\t    <div class=\"o-grid\">   \n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"51\" height=\"48\" viewBox=\"0 0 51 48\"><path id=\"quote\" d=\"M0,48V26.823q0-9.569,3.3-16.157T16.355,0l5.032,9.1q-6.133,2.98-8.178,6.51T11.166,25.1H22.488V48Zm28.354,0V26.823q0-9.569,3.46-16.157T45.024,0l5.032,9.1q-6.133,2.98-8.178,6.51T39.834,25.1H51V48Z\" \/><\/svg>\n\t\t\t\n            <span class=\"c-testimonial-box__text-sub\">Lewis said:<\/span>\n            <p class=\"c-testimonial-box__text\">I\u2019m excited to be taking part in this trial, as by doing so, we could potentially be helping millions of other people in future.<\/p>\n\t            \n\t    <\/div>\n\t \n\t<\/div>\n<\/section>\n<!-- Testimonial Box  -->\n\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<figure id=\"attachment_5196\" aria-describedby=\"caption-attachment-5196\" style=\"width: 300px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-5196\" src=\"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/4\/2021\/09\/jesslewis-300x224.jpg\" alt=\"\" width=\"300\" height=\"224\" srcset=\"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/4\/2021\/09\/jesslewis-300x224.jpg 300w, https:\/\/mft.nhs.uk\/app\/uploads\/sites\/4\/2021\/09\/jesslewis-768x574.jpg 768w, https:\/\/mft.nhs.uk\/app\/uploads\/sites\/4\/2021\/09\/jesslewis-60x45.jpg 60w, https:\/\/mft.nhs.uk\/app\/uploads\/sites\/4\/2021\/09\/jesslewis-680x508.jpg 680w, https:\/\/mft.nhs.uk\/app\/uploads\/sites\/4\/2021\/09\/jesslewis.jpg 902w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-5196\" class=\"wp-caption-text\">Lewis and Jessica while celebrating their anniversary recently<\/figcaption><\/figure>\n<p>\u201cJess struggled with the pill, so we were really interested when we saw the study advertised. We discussed it and decided to apply. Thankfully we did and we were accepted as it has been a positive experience for both of us.<\/p>\n<p>\u201cI have been applying the gel every day since we re-started the trial after the initial lockdown in 2020 and we have been solely reliant upon the contraceptive since October 2020. The application of the gel very quickly became part of my daily morning routine.\u201d<\/p>\n<p>Dan and Emily, who are 34 and 31 respectively, completed the trial in May 2021 and, as they always intended, are now trying for a baby.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<!-- Testimonial Box -->\n<section>\n\t<div class=\"c-testimonial-box\">\n\t    <div class=\"o-grid\">   \n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"51\" height=\"48\" viewBox=\"0 0 51 48\"><path id=\"quote\" d=\"M0,48V26.823q0-9.569,3.3-16.157T16.355,0l5.032,9.1q-6.133,2.98-8.178,6.51T11.166,25.1H22.488V48Zm28.354,0V26.823q0-9.569,3.46-16.157T45.024,0l5.032,9.1q-6.133,2.98-8.178,6.51T39.834,25.1H51V48Z\" \/><\/svg>\n\t\t\t\n            <span class=\"c-testimonial-box__text-sub\">Emily said:<\/span>\n            <p class=\"c-testimonial-box__text\">It\u2019s nice that science has moved forwards to the extent that men and women can share responsibility for contraception \u2013 and this research is empowering from the stance of a woman.<\/p>\n\t            \n\t    <\/div>\n\t \n\t<\/div>\n<\/section>\n<!-- Testimonial Box  -->\n\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]\u201cIt\u2019s quite an antiquated view that men can\u2019t be trusted to take responsibility and it\u2019s so often left to women to deal with that side of things.\u201d<\/p>\n<figure id=\"attachment_5195\" aria-describedby=\"caption-attachment-5195\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-5195\" src=\"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/4\/2021\/09\/danemily.jpg\" alt=\"\" width=\"600\" height=\"399\" srcset=\"https:\/\/mft.nhs.uk\/app\/uploads\/sites\/4\/2021\/09\/danemily.jpg 837w, https:\/\/mft.nhs.uk\/app\/uploads\/sites\/4\/2021\/09\/danemily-300x200.jpg 300w, https:\/\/mft.nhs.uk\/app\/uploads\/sites\/4\/2021\/09\/danemily-768x511.jpg 768w, https:\/\/mft.nhs.uk\/app\/uploads\/sites\/4\/2021\/09\/danemily-60x40.jpg 60w, https:\/\/mft.nhs.uk\/app\/uploads\/sites\/4\/2021\/09\/danemily-680x453.jpg 680w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-5195\" class=\"wp-caption-text\">Dan and Emily on their wedding day<\/figcaption><\/figure>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h3>The value of being part of research<\/h3>\n<p>Dr Fitzgerald, who specialises in infertility, assisted conception and reproductive medicine, said: \u201cResearch is so important and is the only way that the clinical care that we offer to patients can improve.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<!-- Testimonial Box -->\n<section>\n\t<div class=\"c-testimonial-box\">\n\t    <div class=\"o-grid\">   \n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"51\" height=\"48\" viewBox=\"0 0 51 48\"><path id=\"quote\" d=\"M0,48V26.823q0-9.569,3.3-16.157T16.355,0l5.032,9.1q-6.133,2.98-8.178,6.51T11.166,25.1H22.488V48Zm28.354,0V26.823q0-9.569,3.46-16.157T45.024,0l5.032,9.1q-6.133,2.98-8.178,6.51T39.834,25.1H51V48Z\" \/><\/svg>\n\t\t\t\n            <span class=\"c-testimonial-box__text-sub\"> <\/span>\n            <p class=\"c-testimonial-box__text\">Couples taking part in this research now are helping add to the evidence base which could provide others with more options in future.<\/p>\n\t            \n\t    <\/div>\n\t \n\t<\/div>\n<\/section>\n<!-- Testimonial Box  -->\n\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]\u201cI have seen dramatic improvements in fertility care over the past 20 years and we can now offer treatments that were previously only dreamt of.\u201d<\/p>\n<ul>\n<li>The \u2018<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03452111\">Study of Daily Application of Nestorone\u00ae (NES) and Testosterone (T) Combination Gel for Male Contraception\u2019<\/a> is sponsored by the National Institutes of Health, Eunice Kennedy Shriver NICHD and Population Council, Centre for Biomedical research.<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]The NES\/T study is investigating whether daily use of a hormone-based gel is an effective method of contraception for men \u2013 in what could be an historic medical breakthrough and allow men and women to take equal responsibility for birth control in future. Saint Mary\u2019s Hospital, in Manchester, is one of only two UK sites [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":5199,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5],"tags":[172,173,110],"class_list":["post-5194","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-contraceptive","tag-gel","tag-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Couples wanted to be part of pioneering male contraceptive research study \u2013 \u2018NES\/T\u2019 - Saint Mary&#039;s Hospital<\/title>\n<meta name=\"description\" content=\"Couples wanted to be part of pioneering male contraceptive research study\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mft.nhs.uk\/saint-marys\/couples-wanted-to-be-part-of-pioneering-male-contraceptive-research-study-nes-t\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Couples wanted to be part of pioneering male contraceptive research study \u2013 \u2018NES\/T\u2019 - 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