Coagulation reference ranges

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These reference ranges are to help with interpreting results of coagulation tests carried out by the Haematology department.

For children’s or neonate reference ranges please ring laboratory on 0161 701 2123.

For significantly abnormal results, we suggest a discussion with a Haematology Consultant or Senior Registrar.

  • Adult – Haemostasis SPR bleep number 2022
  • Paediatrics – ask switchboard to page Dr Grainger

If you are unable to reach any ward/department with significantly abnormal results which require immediate action, please bleep the lead nurse on 2677.


Activated Partial Thromboplastin Time (APTT) 21.0-30.0 secs
Antithrombin 79-131 u/dl
Bleeding time 2-8 mins
Factor II 78-130 u/dl
Factor V 65-140 u/dl
Factor VII 65-160 u/dl
Factor VIII 50-170 u/dl
Factor IX 60-160 u/dl
Factor X 70-140 u/dl
Factor XI 60-140 u/dl
Factor XII 55-160 u/dl
Factor XIII 60-156d/dl
Fibrinogen 1.7-4.2 g/l
D-DIMER (FDP) <500 ug/ml (VTE assessment)
LMWHeparin(Xa) (approx therapeutic range) 0.30-0.70 u/ml
Prothrombin time 9.9 -11.8 secs
Protein C (Chromogenic) 70-130 u/dl
Protein S (free) 65-135 u/dl
Thrombin Time 15.5-19.4 secs
Von Willebrand Factor Antigen 50-150 u/dl (VWF:AG)
Von Willebrand Factor Activity 50-150 u/dl (Ristocetin Co-factor)

(Last reviewed October 2018)