{"id":966,"date":"2020-07-22T13:04:24","date_gmt":"2020-07-22T12:04:24","guid":{"rendered":"https:\/\/mft.nhs.uk\/trafford\/manchester-doctors-play-leading-role-in-breakthrough-covid-19-drug-research\/"},"modified":"2020-07-22T14:14:53","modified_gmt":"2020-07-22T14:14:53","slug":"manchester-doctors-play-leading-role-in-breakthrough-covid-19-drug-research","status":"publish","type":"post","link":"https:\/\/mft.nhs.uk\/trafford\/manchester-doctors-play-leading-role-in-breakthrough-covid-19-drug-research\/","title":{"rendered":"Manchester doctors play leading role in \u2018breakthrough\u2019 COVID-19 drug research"},"content":{"rendered":"

\"\"Manchester doctors have played a leading role in global coronavirus research, which has found the first drug shown to increase survival rates in people hospitalised with COVID-19.<\/p>\n

The peer-reviewed results of the RECOVERY trial, published in the New England Journal of Medicine on 17 July,<\/a> indicate that the low-cost drug, dexamethasone, \u2018significantly lowers\u2019 death rates in patients hospitalised with severe respiratory complications of COVID-19.<\/p>\n

Dr Tim Felton, an Honorary Consultant at Wythenshawe Hospital \u2013 part of Manchester University NHS Foundation Trust (MFT)<\/a> \u2013 co-authored the paper and leads the study at MFT.<\/a><\/p>\n

Professor Andrew Ustianowski, a Consultant in infectious diseases and tropical medicine at North Manchester General Hospital (NMGH) and the Deputy Clinical Director in Greater Manchester Clinical Research Network<\/a>, is also a co-author. NMGH is run by MFT as part of a management agreement prior to its formal transfer from the Northern Care Alliance NHS Group<\/a>.<\/p>\n

RECOVERY<\/a> is currently taking place at 176 sites across the UK and is sponsored by the University of Oxford<\/a>. It is funded by the National Institute for Health Research (NIHR)<\/a> and UK Research and Innovation (UKRI)<\/a>, and is one of a number of COVID-19 studies that have been given urgent public health research status by the Department of Health and Social Care<\/a>.<\/p>\n

Dr Felton, who is Clinical Lead for all COVID-19-related research studies at MFT as well as a Senior Lecturer in the Division of Infection, Immunity and Respiratory Medicine at The University of Manchester, played an instrumental role in ensuring dexamethasone became part of standard care at MFT from 26 June. This followed shortly after the announcement of the initial results for the dexamethasone arm of the trial earlier in the month. <\/a><\/p>\n

He said: \u201cDexamethasone, which is a type of steroid used in a range of conditions \u2013 typically to reduce inflammation \u2013 is the first drug to improve survival rates in hospitalised coronavirus patients, which truly is a breakthrough.<\/p>\n

\u201cThe short timeframe between our first MFT participant being recruited to the RECOVERY trial in March, to our first COVID-19 patient receiving dexamethasone as a standard NHS treatment in June, is an incredible turnaround.<\/p>\n

\u201cThis could not have happened without patients consenting to take part in research \u2013 which is now directly benefitting all patients admitted to our hospitals with suspected coronavirus \u2013 and I\u2019d like to thank everyone who played their part in this priority COVID-19 research.\u201d<\/p>\n

Another drug, remdesivir, which research has shown helps to shorten recovery times for patients hospitalised with COVID-19<\/a>, was also introduced into standard care at MFT on 26 June. Like dexamethasone, it had previously been part of a research trial at MFT.<\/p>\n

Dr Felton said: \u201cMFT has an established history of delivering cutting-edge clinical research, with the infrastructure, expertise, and staff to enable opening nationally-prioritised COVID-19 studies rapidly and safely, while providing high-quality care for care for trial participants.<\/p>\n

\u201cThis meant we were able to add to the global evidence base, but also make changes here on the ground at MFT very promptly, underlining the vital importance of health research and the rapid impact it can have in a pandemic situation.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

Manchester doctors have played a leading role in global coronavirus research, which has found the first drug shown to increase survival rates in people hospitalised with COVID-19. The peer-reviewed results of the RECOVERY trial, published in the New England Journal of Medicine on 17 July, indicate that the low-cost drug, dexamethasone, \u2018significantly lowers\u2019 death rates […]<\/p>\n","protected":false},"author":2,"featured_media":917,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[11],"tags":[70,8,85,17],"class_list":["post-966","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-covid","tag-manchester","tag-reasearch","tag-research"],"acf":[],"yoast_head":"\nManchester doctors play leading role in \u2018breakthrough\u2019 COVID-19 drug research - Trafford General Hospital<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mft.nhs.uk\/trafford\/manchester-doctors-play-leading-role-in-breakthrough-covid-19-drug-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Manchester doctors play leading role in \u2018breakthrough\u2019 COVID-19 drug research - Trafford General Hospital\" \/>\n<meta property=\"og:description\" content=\"Manchester doctors have played a leading role in global coronavirus research, which has found the first drug shown to increase survival rates in people hospitalised with COVID-19. 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