{"id":2734,"date":"2021-09-02T14:55:39","date_gmt":"2021-09-02T13:55:39","guid":{"rendered":"https:\/\/mft.nhs.uk\/wythenshawe\/woman-who-has-lived-with-cough-for-30-years-receives-world-first-dose-of-potential-new-cough-treatment-at-wythenshawe-hospital\/"},"modified":"2021-09-02T14:05:30","modified_gmt":"2021-09-02T14:05:30","slug":"woman-who-has-lived-with-cough-for-30-years-receives-world-first-dose-of-potential-new-cough-treatment-at-wythenshawe-hospital","status":"publish","type":"post","link":"https:\/\/mft.nhs.uk\/wythenshawe\/woman-who-has-lived-with-cough-for-30-years-receives-world-first-dose-of-potential-new-cough-treatment-at-wythenshawe-hospital\/","title":{"rendered":"Woman who has lived with cough for 30 years receives world-first dose of potential new cough treatment at Wythenshawe Hospital"},"content":{"rendered":"

[vc_row][vc_column]

\n <\/p>\n

A 70-year-old woman, forced to live with cough since her 40s, is \u2018excited\u2019 to be the first person in the world to receive a potential new cough treatment at the NIHR Manchester Clinical Research Facility<\/a>\u00a0(CRF)<\/u>.<\/h3>\n

\n<\/div>\n[\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]The global research lead for the study, Professor Jacky Smith, Consultant at Wythenshawe Hospital, part of Manchester University NHS Foundation Trust (MFT)<\/a>, and Professor of Respiratory Medicine at The University of Manchester<\/a>, has played an integral role in the worldwide search for a treatment of chronic cough (a cough lasting eight or more weeks).<\/p>\n

Chronic cough can be caused by an underlying respiratory condition, such as chronic obstructive pulmonary disease<\/a>\u00a0(COPD) or asthma<\/a>, or by a non-respiratory underlying condition, such as gastroesophageal reflux disease<\/a>\u00a0(GORD). There are also some people who suffer from a chronic cough that is unexplained.<\/p>\n

Coughing is a way in which our bodies get rid of foreign particles, irritants, microbes, mucus and bacteria \u2013 among other allergens from the throat \u2013 and is an important defence mechanism. Sensory nerves in the airways play a role in generating the body\u2019s cough response and are activated in response to cough stimuli.<\/p>\n

Dr Paul Marsden is the study lead at NIHR Manchester CRF. He, and the other searchers involved in this clinical trial, sponsored by Nocion Therapeutics<\/a>, believe that when inhaled, using a nebuliser, the study drug, NOC-100, might be able to reduce cough by directly targeting and reducing the activation of the sensory nerves in airways.<\/p>\n

\"\"
Joan relaxing at home.<\/figcaption><\/figure>\n

Joan, from Stockport, who is the first global participant in the study, said: \u201cI am taking part in this research for mainly selfish reasons \u2013 I want a cure for my persistent cough!<\/p>\n

\u201cI\u2019ve lived with my cough for 30 years, and in that time, I\u2019ve had people show concern for me, offering various forms of help, from cough sweets to hot herbal drinks. However, I\u2019ve also been asked to leave shops, move seats on public transport, or sit outside at restaurants and bars.\u201d<\/p>\n

\u201cEven when people try to be kind it can be really humiliating. On one occasion I was in a nice restaurant and I couldn\u2019t stop coughing. A waiter rushed to my aid mistakenly thinking I was choking on some food and used the Heimlich Manoeuvre on me. Unfortunately, as I didn\u2019t have a blockage in my throat, I was violently sick in front of the whole restaurant. I was so embarrassed I had to leave.<\/p>\n

\u201cI can laugh about that incident now and I know this research might not help me directly, but many people with a cough are so embarrassed by it \u2013 they limit where they go and what they do in public places \u2013 and this is such an unhappy situation to be in. We need to find a cure.\u201d<\/p>\n

\"\"
Dr Jenny King, Clinical Research Fellow, sub investigator on the study, checking on Joan after she\u2019s received a dose of the study drug.<\/figcaption><\/figure>\n

Professor Smith, who is Director of Manchester CRF and Programme Lead for Improving Respiratory Symptoms within the NIHR Manchester Biomedical Research Centre (BRC)<\/a>, said: \u201cLong-term chronic cough can have a huge impact on someone\u2019s life. It is more than just an annoyance. It can cause a list of unwelcome effects, including anxiety, depression and exhaustion.\u201d<\/p>\n

\u201cI’ve spent my career seeing patients in my specialist clinic for the investigation and treatment of chronic cough, and conducting clinical research aimed at finding therapies for those patients whose cough is resistant to treatment.<\/p>\n

\u201cIf proven to be safe and effective, NOC-100 has the potential to have a beneficial impact on the lives of people with this distressing condition.\u201d<\/p>\n

The study is being carried out in the United Kingdom and Germany.<\/p>\n

Dr Christopher Silber, Chief Medical Officer at Nocion Therapeutics, said: \u201cWe are very excited to begin clinical investigation of NOC-100 in patients suffering from chronic cough.<\/p>\n

\u201cCough is a common and debilitating symptom that affects millions of people with few available treatment options. We believe NOC-100 may have broad potential in the treatment of cough, including chronic cough.<\/p>\n

\u201cAs we evolve to this next stage of development, we are extremely pleased to be working with premier research centres like the NIHR Manchester Clinical Research Facility, under the direction of global cough experts such as Professor Jacky Smith and Dr Paul Marsden, and their experienced clinical research team.\u201d[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]The global research lead for the study, Professor Jacky Smith, Consultant at Wythenshawe Hospital, part of Manchester University NHS Foundation Trust (MFT), and Professor of Respiratory Medicine at The University of Manchester, has played an integral role in the worldwide search for a treatment of chronic cough (a cough lasting eight or more weeks). Chronic […]<\/p>\n","protected":false},"author":2,"featured_media":2746,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[10],"tags":[160,161,18],"class_list":["post-2734","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-cought","tag-smoking","tag-wythenshawe"],"acf":[],"yoast_head":"\nWoman who has lived with cough for 30 years receives world-first dose of potential new cough treatment at Wythenshawe Hospital - Wythenshawe Hospital<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mft.nhs.uk\/wythenshawe\/woman-who-has-lived-with-cough-for-30-years-receives-world-first-dose-of-potential-new-cough-treatment-at-wythenshawe-hospital\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Woman who has lived with cough for 30 years receives world-first dose of potential new cough treatment at Wythenshawe Hospital - Wythenshawe Hospital\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]The global research lead for the study, Professor Jacky Smith, Consultant at Wythenshawe Hospital, part of Manchester University NHS Foundation Trust (MFT), and Professor of Respiratory Medicine at The University of Manchester, has played an integral role in the worldwide search for a treatment of chronic cough (a cough lasting eight or more weeks). 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