EMERGING

CMFT Emergency Department is an academic department with a strong track record for producing high quality research over many years.  Our doctoral research fellowships have been kick starting the careers of the country’s most promising academic emergency physicians for well over a decade.  The work we have produced has influenced national guidelines (including the current NICE paediatric head injury guideline) and international guidelines (including the latest International Liaison Committee Guideline for Acute Coronary Syndromes).  We have written evidence-based national guidelines (GEMNet guidelines for tricyclic antidepressant overdose, lone acute severe headache and anaphylaxis).  Our work has been published in high impact journals including the BMJ, Lancet and Journal of the American College of Cardiology.  We are also the home of Best BETs from the Manchester Royal Infirmary, which are published in the Emergency Medicine Journal and Archives of Disease in Childhood.

We currently support a number of clinical research studies including

• ART-123: A multicentre double blind randomised phase III CTIMP (Clinical Trial of an Investigational Medical Product) for patients with severe sepsis and coagulopathy.

• BEST: A multi-centre observational study of patients with suspected cardiac chest pain.  Bloods are taken at 0 and 3 hours for lab troponins and Point of Care troponins and H-FABP (another cardiac marker). These are compared with the patient’s outcome and 12 hour troponin. The aim is to see whether a 3 hour troponin is an adequate rule out for chest pain, and to see if the POC tests are good enough to use diagnostically.
• Biomarkers in Trauma: An observational study of major trauma patients testing sequential blood samples for specific immune biomarkers (T-Cells and Cytokines). The researchers want to develop a predictive model for organ dysfunction and mortality. This is in collaboration between Salford University and CMFT.
• B04-01 (Multi Stem ARDS): A multi-centre double blind randomised phase II CTIMP of Stem Cell Therapy v Placebo in patients with ARDS (Acute Respiratory Distress Syndrome) a potentially life threatening condition.
• Crash 3: A clinical trial investigating the effectiveness of Tranexamic Acid in traumatic head injuries.
• Halt-it: A similar clinical trial to Crash 3, investigating the effectiveness of Tranexamic Acid in gastrointestinal bleeding.
• IONA: Identification and characterisation of the clinical toxicology of Novel Psychoactive Substances (NPS) by laboratory analysis of biological samples from recreational drug users.
• Bravo: A diagnostic study of patients with suspected VAP by the use of a Non-Invasive breath analysis device.to aid in antibiotic usage.
• REST: A multi-centre randomised interventional study using the A-Lung extracorporeal CO2 removal system for patients with Acute Respiratory Failure/ ARDS. One of the aims is to reduce Tidal Volumes to 3-4 mls/kg.
• MARINER: A multi-centre double blind randomised trial of Rivaroxaban Versus Placebo IN Reducing Post-Discharge Venous Thrombo-Embolism Risk.
• PRISM – Prevention of Respiratory Insufficiency after Surgical Management (PRISM) Trial: A pragmatic randomised controlled trial of continuous positive airway pressure (CPAP) to prevent respiratory complications and improve survival following major abdominal surgery.
• Improving Tracheostomy Care – National Quality Improvement Programme. The Improving Tracheostomy Care (ITC) project aims to improve the care for tracheostomy patients everywhere through a large demonstration programme in geographically, demographically and politically diverse hospitals in the UK.
• STUMBL – A multi-centre randomised feasibility study evaluating the impact of a prognostic model for management of blunt chest wall trauma patients.
• NO-Pac – Novel use of Tranexamic Acid to reduce the need for Nasal Packing in Epistaxis. Investigating a new treatment to help control nose bleeds.
• D-Dimer – Sample Collection in support of Clinical Performance Evaluation of the Roche Tina-quant^® D-Dimer Gen. 2 assay for c4c family in the evaluation of patients with suspected Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE) with or without Deep Vein Thrombosis. To discover if a new blood test is as accurate as an existing one in diagnosing blood clots in the legs and lungs.

Personnel