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Our clinical service covers the North West of England and we run a national centre (Northern Congenital Hyperinsulinism service, NORCHI) for the rare disorder of congenital hyperinsulinism.

Our endocrine (hormone-related) research, conducted in collaboration with our main research partner The University of Manchester, focuses on growth and metabolism, bone disorders, obesity and diabetes and CHI.

Research Themes:

Growth and metabolism

  • 3M syndrome and related conditions
  • Pharmacogenomics of growth hormones
  • Relationship between pregnancy, fetal growth and longer term growth outcomes

Bone and vitamin D disorders

  • Hypophosphatasia (HPP)
  • Bone architecture and muscle-bone infrastructure
  • X-linked hypophosphatemic rickets
  • Glucocorticoid induced osteoporosis



  • Type 1 and type 2 diabetes

Congenital Hyperinsulism (CHI)

  • Understanding the phenotype (disease pattern) of CHI
  • Improving existing medical therapies for CHI
  • Understanding the pathobiology (molecular mechanism of disease) of CHI
  • Identifying new targets for CHI therapy
If you are interested in finding out more about clinical research and how you can get involved, please ask a member of your medical team or visit our get involved page.