Research in Breast Cancer Screening led by Professor Gareth Evans is at an exciting stage where progress is being made following on from the Predicting-Risk-Of-Cancer-At-Screening (PROCAS-1) study.
In PROCAS-1, at the time of breast screening, a woman’s individual risk of developing breast cancer was estimated from a questionnaire (on paper) including key risk factors (such as lifestyle and family history of cancer) and by estimating their breast density (the amount of tissue in the breast that is not fat) from their mammogram. In this study it was encouraging to discover that over 94% of 58,000 women wished to know their personal risk of breast cancer.
In the current PROCAS-2 programme which began in summer 2017 and is led by Professor Evans at Manchester University Foundation Trust (MFT), the research team in Manchester is automating the risk prediction process using an online system called BC-Predict.
Invited women log onto a website where they answer questions in the risk questionnaire. Their mammogram results are pulled in automatically and together the questionnaire answers and breast density results from the mammogram are combined to produce a 10-year breast cancer risk. The BC-Predict system allows an automatically generated letter to be produced which is then sent to women and their GP to inform them of their breast cancer risk.
Access to the online questionnaire is via web link and is currently only available for those women invited to participate in the study:
The PROCAS-2 program will run for a total of 3 years, starting with a small pilot study to demonstrate that BC-Predict performs as expected. This will be followed by an 8000 women study across Greater Manchester, East Cheshire and East Lancashire sites.
MFT will own all Intellectual Property created by participating sites and contributors as a result of this programme of work.