Clinical Genetics is a medical discipline specialising in the diagnosis and management of conditions with a known or probable genetic basis, for which genomic discoveries are revolutionising care. Genetic disorders occur across the whole lifespan and may affect multiple family members and generations. Families often require both specialist diagnosis and health management.
Genomic Medicine (Manchester Centre for Genomic Medicine; MCGM) is an integrated and multidisciplinary facility which brings together NHS patient services and genomic researchers. It is one of the UK’s largest genetics centres with in excess of 250 staff, enabling us to offer a wide range of routine and specialist genomic services and to use knowledge from research discoveries to improve clinical care.
Clinical Services
Our clinical services cover the Greater Manchester region as well as parts of Cheshire, Lancashire and Cumbria. We provide a comprehensive service for prenatal genetics, dysmorphology, neuromuscular genetics, neuropsychiatric genetics, ophthalmic genetics, cardiac genetics and cancer genetics. Clinical diagnostic and counselling services are provided from clinics in the centre, at The Christie Hospital and in a number of district general hospitals throughout the North West of England. The unit is a major training centre for specialist registrars, scientists and for professionals from other disciplines.
Laboratory
The NW GLH (North West Genomic Laboratory Hub offers clinical diagnostic tests for single gene and genomic disorders. Nucleic acid and cytogenetics based tests are offered for the full range of tests defined in the NHSE Rare Disease and Cancer Test Directories. Available tests cover a broad range of inherited and acquired disorders including germline diagnostic, carrier, predictive and prenatal tests as well as somatic testing in tumours from cancer patients (haematology oncology and solid tumours).
Research / Education
We have an active programme of research exploring ways to increase our ability to personalise diagnosis, to understand the effect of gene changes, to predict response to drugs and to offer patients new treatment opportunities. We have a diverse portfolio of active research studies and active clinical trials providing our patients with a wide range of opportunities to take part in research. As Genetics and Genomics is an important and rapidly evolving science in healthcare, we also have an extensive programme of teaching including the Clinical Scientist Training Programme in Genomics, which trains Genomic Scientists, Genomic Counsellors and Bioinformaticians for the current and future healthcare delivery.
Useful links
Manchester Genetics Website https://www.mangen.co.uk
Information on the NF1 service
NHS England Information on NF1
Consultants
- Dr Siddharth Banka - Consultant Clinical Geneticist
- Professor Graeme Black - Honorary Consultant in Genetics/Ophthalmology
- Dr Catherine Breen - Consultant Clinical Geneticist
- Dr Tracy Briggs - Consultant Clinical Geneticist
- Dr Emma Burkitt-Wright - Consultant Clinical Geneticist
- Dr Kate Chandler - Consultant Clinical Geneticist
- Dr David Craufurd - Honorary Consultant and Senior Lecturer in Neuropsychiatric Genetics
- Dr John Ealing - Consultant Neurologist and Director of the Greater Manchester Motor Neurone Disease Care Centre
- Professor Gareth Evans - Professor in Medical Genetics and Cancer Epidemiology
- Georgina Hall - Consultant Genetic Counsellor & Honorary Lecturer
- Dr Elizabeth Jones - Consultant in Clinical Genetics
- Dr Simon Jones - Consultant in Paediatric inherited metabolic disease, Senior Lecturer at The University of Manchester
- Dr Fiona Lalloo - Consultant Clinical Geneticist
- Dr Rhona MacLeod - Consultant Genetic Counsellor and Lecturer in Medical Genetics
- Dr Kay Metcalfe - Consultant Clinical Geneticist
- Dr Andrew Morris - Consultant Paediatrician, Lead Clinician in Metabolic Medicine and Honorary Senior Lecturer at The University of Manchester
- Professor Bill Newman - Clinical Head of Division and Senior Lecturer in Clinical Genetics
- Dr Bernd C Schwahn - Consultant Clinical Paediatrician in Inherited Metabolic Medicine
- Dr Audrey Smith - Consultant Clinical Geneticist
- Dr Helen Stuart - Consultant Clinical Geneticist and Honorary Senior Lecturer at the University of Manchester
- Dr Grace Vassallo - Consultant Paediatric Neurologist and Clinical Lead for the Complex NF1 service at Saint Mary`s Genomic Centre for Medicine
- Dr Emma Woodward - Consultant Clinical Geneticist