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During normal T and B-lymphocyte development the genes encoding T-cell receptor and immunoglobulin molecules rearrange and mutate resulting in each individual cells having a unique genetic signature. This expands the immune system’s ability to respond to infection. Any malignant clone arising from one of these cells will therefore share this signature, detection of which can provide important evidence of cancer.

The laboratory undertakes Immunoglobulin and T cell receptor clonality analysis as part of a multidisclipinary approach to Lymphoma diagnosis.

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