In this section
The Vaccine Evaluation Unit (VEU) specialises in serological determination of immune responses to Neisseria meningitidis and Streptococcus pneumoniae either following vaccination or disease. It has international recognition for all of the assays that encompass serum bactericidal antibody assays and ELISA for all serogroups of N. meningitidis as well as offering determination of IgG concentrations for pneumococcal (serotype-specific), Haemophilus influenzae type b, tetanus and diphtheria. The VEU underpinned the implementation of the meningococcal serogroups C and ACWY conjugate vaccines and the serogroup B protein-based vaccine in the U.K. with performance of meningococcal serological assays and redefinition of the correlates of protection.
The VEU was involved in a similar project that led to the implementation of a serogroup A vaccine in Sub-Saharan Africa, and is involved in an ongoing project regarding the introduction of a pentvalent ACWYX conjugate vaccine. It offers a range of validated assays for meningococcal serogroup B and is involved in many vaccine trials both here and overseas. The pneumococcal serology assays provided by the VEU are now widely used by clinicians as well as for vaccine trials.
The VEU also houses the PHE Seroepidemiology Unit (SEU), part of the Serum Archive Section. The VEU has been involved in serosurveys for pneumococcal antibodies, meningococcal serogroups A, C, Y and W as well as serogroup B serology and human papilloma virus IgG. The total workload is approximately 200,000 assays per annum.
The VEU has an active research programme and encourages collaborations locally, nationally and internationally. Ongoing projects include novel platforms for multiplexing assays. Nationally the VEU is a key player in the National Immunisation Schedule Evaluation Consortium and the UK Paediatric Vaccine Group whilst internationally it advises WHO on serological assays for meningococci and tetanus and maintains strong links to most vaccine manufacturers, who use the Unit as a reference centre. The VEU is also committed to training of staff from laboratories both nationally and internationally, particularly those from developing countries.
Laboratory opening hours
The VEU is open:
Monday to Friday: 8.00am – 5.00pm
Clinical advice
A full clinical advice service is maintained.
For advice during normal working hours: Tel: 0161 276 6793 or 0161 276 5697 or 0161 276 6791
Results
For general results/enquiries:
Tel: 0161 276 8854 or 0161 276 8788
Out-of-hours service
There is no out-of-hours service for the Vaccine Evaluation Unit.
Contact details
| Name | Email address | External No | Internal No |
| Prof Ray Borrow Head of VEU Consultant Clinical Scientist |
ray.borrow@phe.gov.uk | 0161 276 8850 | 68850 |
| Dr Ezra Linley Deputy Head of VEU |
ezra.linley@phe.gov.uk | 0161 701 5303 | 15303 |
| Simon Tonge Serum Archives |
simon.tonge@phe.gov.uk | 0161 276 6791 | 66791 |
| Mrs Nicola Boothman PA/Unit Administrator |
nicola.boothman@phe.gov.uk | 0161 276 6793 | 66793 |
| Mrs Ellen Kirkwood PA/Unit Administrator |
ellen.kirkwood@phe.gov.uk | 0161 276 8842 | 68842 |
| Mrs Nilofer Razzaq PA/Unit Administrator |
nilofer.razzaq@phe.gov.uk | 0161 276 6793 | 66793 |
| VEU Fax No: | 0161 276 5744 | ||
Postal Address:
Vaccine Evaluation Unit
MMMP,
2nd Floor CSB2,
PO Box 209,
Manchester Royal Infirmary
Oxford Road,
Manchester,
M13 9WL
Courier Delivery Address:
Vaccine Evaluation Unit
MMMP,
2nd Floor CSB2,
Manchester Royal Infirmary
Oxford Road,
Manchester,
M13 9WL
DX Address:
Manchester Medical Microbiology Partnership
DX6962410
Manchester 90 M
(Last reviewed June 2021)